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Sridhar BHAVANI, David P. HODSON, Julio HUERTA-ESPINO, Mandeep S. RANDHAWA, Ravi P. SINGH
《农业科学与工程前沿(英文)》 2019年 第6卷 第3期 页码 210-224 doi: 10.15302/J-FASE-2019268
Races belonging to the Ug99 (TTKSK) lineage of the wheat stem rust fungus, carrying complex virulence combinations, and their migration to countries in Africa, Middle East and Asia continue to pose a significant threat to global wheat production. The rapid spread of additional races, e.g., TKTTF or the Digalu lineage, in several countries causing localized epidemics reminds us of the vulnerability of wheat germplasm to stem rust disease, a formidable foe referenced as early as biblical times. A global rust monitoring system reflecting increased surveillance efforts has identified 13 races within the Ug99 lineage in 13 countries and unrelated lineages are emerging, spreading and posing serious threats to wheat production. Race TKTTF has caused localized epidemics in Ethiopia and its variants have been recently implicated in stem rust outbreaks in Europe. Concerted research efforts have resulted in the identification of several new resistance (APR) genes and gene combinations for use in breeding. Combining multiple adult plant resistance genes in high-yielding backgrounds and discovery of new quantitative trait loci conferring stem rust resistance has progressed in the recent years, enhancing the durability of resistance. Effective gene stewardship and new generation breeding materials and cultivars that combine multiple race-specific or minor to intermediate effect APR genes, complemented by active surveillance and monitoring, have helped to limit major epidemics and increase grain yield potential in key target environments.
关键词: adult plant resistance black rust race-specific resistance Triticum aestivum
Xu Zhang, Huanhuan Yang, Xinlei Wang, Wen Song, Zhaojie Cui
《环境科学与工程前沿(英文)》 2018年 第12卷 第4期 doi: 10.1007/s11783-018-1059-2
SFE-GC system is established for flavonols assessment. Optimal parameters of SFE-GC are evaluated and determined. Quercetin and kaempferol are detected in plant under heavy metal stress. Gene expression analysis shows consistent regularity with content of flavonols. ROS level is applied for elaborating the plant resistance status.
关键词: Flavonols Heavy metal Supercritical carbon dioxide extraction (SFE) GC Plant resistance
《环境科学与工程前沿(英文)》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1682-4
● Abundance of MAGs carrying ARG-VF pairs unchanged in rivers after WWTP upgrade.
关键词: Wastewater treatment plant upgrade Antibiotic resistance genes (ARGs) Virulence factors (VFs) Gene co-occurrence Genome-centric analysis
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
《农业科学与工程前沿(英文)》 2020年 第7卷 第3期 页码 329-332 doi: 10.15302/J-FASE-2020333
The use of antibiotics in human medicine and animal husbandry has resulted in the continuous release of antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistance. The spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens is one of the most intractable clinical challenges. Numerous studies have been conducted to profile the patterns of ARGs in agricultural ecosystems, as this is closely related to human health and wellbeing. This paper provides an overview of the transmission of ARGs in agricultural ecosystems resulting from the application of animal manures and other organic amendments. The future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems is also discussed, particularly from a holistic perspective, and requires multiple sector efforts to translate fundamental knowledge into effective strategies.
关键词: agroecosystem antibiotic resistance public health soil-plant system
Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe
YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong
《医学前沿(英文)》 2008年 第2卷 第2期 页码 130-133 doi: 10.1007/s11684-008-0024-z
China-CIMMYT collaboration enhances wheat improvement in China
Zhonghu HE, Xianchun XIA, Yong ZHANG, Yan ZHANG, Yonggui XIAO, Xinmin CHEN, Simin LI, Yuanfeng HAO, Awais RASHEED, Zhiyong XIN, Qiaosheng ZHUANG, Ennian YANG, Zheru FAN, Jun YAN, Ravi SINGH, Hans-Joachim BRAUN
《农业科学与工程前沿(英文)》 2019年 第6卷 第3期 页码 233-239 doi: 10.15302/J-FASE-2019254
China and CIMMYT have collaborated on wheat improvement for over 40 years and significant progress has been achieved in five aspects in China. A standardized protocol for testing Chinese noodle quality has been established with three selection criteria, i.e., gluten quality, starch viscosity and flour color are identified as being responsible for noodle quality. Genomic approaches have been used to develop and validate gene-specific markers, leading to the establishment of a KASP platform, and seven cultivars have been released through application of molecular marker technology. Methodology for breeding adult-plant resistance to yellow rust, leaf rust and powdery mildew, based on the pleiotropic effect of minor genes has been established, resulting in release of six cultivars. More than 330 cultivars derived from CIMMYT germplasm have been released and are now grown over 9% of the Chinese wheat production area. Additionally, physiological approaches have been used to characterize yield potential and develop high-efficiency phenotyping platforms. CIMMYT has also provided valuable training for Chinese scientists. Development of climate-resilient cultivars with application of new technology will be the priority for future collaboration.
关键词: adult-plant resistance bread wheat breeding gene-specific marker germplasm exchange processing quality
Advances in immunopathogenesis of adult immune thrombocytopenia
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 418-424 doi: 10.1007/s11684-013-0297-8
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.
关键词: primary immune thrombocytopenia B lymphocytes T lymphocytes antigen-presenting cells cytokines
Lian Yang, Qinxue Wen, Zhiqiang Chen, Ran Duan, Pan Yang
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1116-5
The distributions of ARGs were monitored in a WWTP in Harbin during six months. CASS had the best removal efficacy of ARGs compared to other processes in the WWTP. UV disinfection could effectively control the HGT. AGAC significantly remove ARGs and organics due to its high absorption capacity. Combination of ozone and AGAC significantly improve removal of ARGs and organics.
关键词: Antibiotic resistance genes (ARGs) Wastewater treatment plant (WWTP) Ultraviolet (UV) Ozonation Granular activated carbon (GAC)
Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes
Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1120-9
Reviewed the change of ARGs and ARB in full-scale urban drinking water systems. Conventional processes are more promising than BAC process in ARGs removal. Mechanisms of ARGs enrichment and spread in BAC filter and DWDSs are discussed. Raise the need of future research on ARGs and ARB change in building plumbing systems.
关键词: Antibiotic resistant bacteria Antibiotic resistance genes Water source Drinking water treatment plant Drinking water distribution system Urban drinking water system
YAN Lunan, ZENG Yong, WEN Tianfu, ZHAO Jichun, WANG Wentao, YANG Jiayin, XU Mingqing, MA Yukui, CHEN Zheyu, LIU Jiangwen, WU Hong
《医学前沿(英文)》 2007年 第1卷 第2期 页码 136-141 doi: 10.1007/s11684-007-0026-2
《医学前沿(英文)》 页码 939-956 doi: 10.1007/s11684-023-0987-9
关键词: mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing cardiac regeneration
Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 333-339 doi: 10.1007/s11684-017-0564-1
Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosuppressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell–matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.
关键词: nephrotic syndrome focal segmental glomerulosclerosis genetic
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
《医学前沿(英文)》 2023年 第17卷 第2期 页码 240-262 doi: 10.1007/s11684-022-0936-z
关键词: glioma progression molecular classification EM/PM subtyping intratumor heterogeneity
Emergency adult living donor right lobe liver transplantation for fulminant hepatic failure
ZHANG Feng, WANG Xuehao, LI Xiangcheng, KONG Lianbao, SUN Beicheng, LI Guoqiang, QIAN Xiaofen, CHEN Feng, WANG Ke, LU Sheng, PU Liyong, LU Ling
《医学前沿(英文)》 2007年 第1卷 第3期 页码 282-286 doi: 10.1007/s11684-007-0054-y
null
《医学前沿(英文)》 2017年 第11卷 第2期 页码 229-238 doi: 10.1007/s11684-017-0506-y
A CALLG2008 protocol was developed by the Chinese Acute Lymphoblastic Leukemia Cooperative Group for adult acute lymphoblastic leukemia (ALL). We retrospectively analyzed 153 newly diagnosed adult patients with Philadelphia chromosome (Ph)-positive ALL enrolled into imatinib (400 mg/d) plus CALLG2008 regimen between 2009 and 2015. The median age was 40 years (range, 18–68 years), with 81 (52.3%) males. The overall hematologic complete remission (CR) rate was 96.7% after induction. With a median follow-up of 24.2 months, the estimated 3-year overall survival (OS) and event-free survival (EFS) rates were 49.5% (95% confidence interval (CI): 38.5%–59.5%) and 49.2% (95% CI: 38.3%–59.2%), respectively. Fifty-eight (36 with haploidentical donor) patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first CR. Among the patients in CR1 after induction, both the 3-year OS and EFS were significantly better in the allo-HSCT group than in the without allo-HSCT group (73.2%, 95% CI: 58.3%–83.5% vs. 22.2%, 95% CI: 8.7%–39.6% and 66.5%, 95% CI: 50.7%–78.2% vs. 16.1%, 95% CI: 5.1%–32.7%, respectively). Multivariate analysis showed that allo-HSCT and achievement of major molecular response were associated with favorable OS or EFS independently. Interestingly, in the allo-HSCT cohort, the donor type (haploidentical versus matched donors) had no significant impact on EFS or OS. All these results suggested that imatinib plus CALLG2008 was an effective protocol for Ph-positive ALL. Haploidentical donors can also be a reasonable alternative expedient donor pool.
关键词: Philadelphia chromosome acute lymphoblastic leukemia imatinib CALLG2008
标题 作者 时间 类型 操作
Progress in breeding for resistance to Ug99 and other races of the stem rust fungus in CIMMYT wheat germplasm
Sridhar BHAVANI, David P. HODSON, Julio HUERTA-ESPINO, Mandeep S. RANDHAWA, Ravi P. SINGH
期刊论文
An extraction- assay system: Evaluation on flavonols in plant resistance to Pb and Cd by supercritical
Xu Zhang, Huanhuan Yang, Xinlei Wang, Wen Song, Zhaojie Cui
期刊论文
Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulencefactors in receiving rivers: Benefits of wastewater treatment plant upgrade
期刊论文
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
期刊论文
Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe
YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong
期刊论文
China-CIMMYT collaboration enhances wheat improvement in China
Zhonghu HE, Xianchun XIA, Yong ZHANG, Yan ZHANG, Yonggui XIAO, Xinmin CHEN, Simin LI, Yuanfeng HAO, Awais RASHEED, Zhiyong XIN, Qiaosheng ZHUANG, Ennian YANG, Zheru FAN, Jun YAN, Ravi SINGH, Hans-Joachim BRAUN
期刊论文
Impacts of advanced treatment processes on elimination of antibiotic resistance genes in a municipalwastewater treatment plant
Lian Yang, Qinxue Wen, Zhiqiang Chen, Ran Duan, Pan Yang
期刊论文
Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes
Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma
期刊论文
Preliminary experience in adult-to-adult living donor liver transplantation in a single center in China
YAN Lunan, ZENG Yong, WEN Tianfu, ZHAO Jichun, WANG Wentao, YANG Jiayin, XU Mingqing, MA Yukui, CHEN Zheyu, LIU Jiangwen, WU Hong
期刊论文
mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic and adult
期刊论文
Emergency adult living donor right lobe liver transplantation for fulminant hepatic failure
ZHANG Feng, WANG Xuehao, LI Xiangcheng, KONG Lianbao, SUN Beicheng, LI Guoqiang, QIAN Xiaofen, CHEN Feng, WANG Ke, LU Sheng, PU Liyong, LU Ling
期刊论文